MAPT and neuroblastoma: To unravel whether MAPT-AS1 would regulate MAPT/tau expression in human neurons we used distinct human in vitro cellular models, including two neuroblastoma cell lines (SK-N-MC and SH-SY5Y) and a model of Ngn2-induced human iPSC-derived neurons (NGN2-neurons), which have also been used in previous studies [21, 29].