Notably, Vegfa macrophages and Proinflammatory macrophages exhibited downregulation of tumor angiogenesis and protumorigenic genes (e.g., Cxcl3, Cxcl1, S100a8, SPP1) and upregulation of immune cell recruitment‐associated genes (e.g., Cxcl9, Ccl5, Ccl8) in mRNA‐treated groups (Figure S7e, Supporting Information). This evidence concerns the gene SPP1 and neoplasm.