Although androgen excess, oligo-menorrhea/anovulation, and the existence of polycystic-like ovarian morphology are the key diagnostic indicators for PCOS, a common secondary feature is increased luteinizing hormone (LH) pulsatility (Waldstreicher et al., 1988, Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group, 2004). Here, PLOD1 is linked to hyperandrogenism.