As such, it is thought that dysfunction within the ARNKISS neuron pulse generator may be responsible for the elevated LH pulse frequency observed in PCOS (Walters et al., 2018; Coutinho and Kauffman, 2019; Rodriguez Paris and Bertoldo, 2019; Ruddenklau and Campbell, 2019). Here, PLOD1 is linked to polycystic ovary syndrome.