CLOCK and Alzheimer disease: Of note, Neu-In clock CpGs defining cis-mQTLs in adult brain also included SNPs that mapped to CASS4. In addition, another Neu-In/Neu-Sin clock CpG defines a cis-mQTL in brain mapping to the TSPAN14 gene (Supplementary Figure 18D), which is associated with increased AD risk [85, 88, 89].