Thus, white adipose tissue in obesity secretes a spectrum of proinflammatory molecules, including IL‐6, IL‐8, IL‐17, IL‐23, monocyte chemoattractant protein‐1 (MCP‐1), plasminogen activator inhibitor 1 (PAI‐1), establishing systemic obesity's chronic low‐grade inflammation. The gene discussed is SERPINE1; the disease is obesity due to melanocortin 4 receptor deficiency.