Adapted to the principle of fusion gene breakpoint detection in pediatric Ewing sarcomas harboring EWS-FLI1 fusions (32) and KMT2A- or ETV6/RUNX1-positive acute lymphoblastic leukemias (33, 34), we provide proof-of-concept for the similar detection of TERT rearrangement breakpoints in a highly aggressive and often deadly molecular high-risk neuroblastoma subgroup. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.