[71] established NPs of Cu2-–xSe for dual-modal imaging-guided photothermal therapy of cancer, featuring tunable LSPR and magnetism, using vacancy specifically show how a complex matrix including 50% human serum can quickly identify prostate-specific antigen and human alpha-fetoprotein, two major cancer indicators, present in amounts as low as 500 pg/mL. This evidence concerns the gene KLK3 and cancer.