AQP4 and myopia: These considerations are consistent with the central role of Müller cells in myopia, because the endfeet of these cells express aquaporin 4 at interfaces with retinal capillaries, the vitreoretinal border and synapses in the plexiform layers to facilitate retinal signal transduction (Goodyear et al., 2008; Nagelhus et al., 1998; Iandiev et al., 2007).