Although EP is classified as a subtype of psoriasis, the pathogenic processes are distinct from those seen in plaque psoriasis [11], IL36RN mutations have been linked to pustular psoriasis, and the class I antigens HLA-Cw6, HLA-B57, HLA-B13, and HLA-B17 have been linked to psoriasis vulgaris. The gene discussed is IL36RN; the disease is pustular psoriasis.