In the study conducted by Spec et al., it was noted that an AST/ALT ratio of 2.5 or higher (95% CI: 1.22-4.16) was more strongly correlated with disseminated histoplasmosis than with other mycoses or pulmonary histoplasmosis, which exhibited a lower AST/ALT ratio (P < 0.0001) [9]. The gene discussed is GPT; the disease is opportunistic mycosis.