Different types of tolerogenic vaccination with IL-2 treatment in combination with antigen exposure suppressed disease in models of EAE (109), experimental autoimmune uveitis (EAU) (110, 111), T1D (112), delayed-type hypersensitivity (DTH) (112), and reduced development of anti-drug antibodies toward FVIII in hemophilia A (113). This evidence concerns the gene F8 and hemophilia A.