Tolerogenic vaccination with microparticles containing GM-CSF and TGF-β1 alongside nanoparticles with antigen and vitamin D suppressed EAE and T1D (88–92) and microparticles loaded with TGF-β, retinoic acid, and autoantigens suppressed T1D (93) (Table 5). This evidence concerns the gene CSF2 and type 1 diabetes mellitus.