KLF4 and Alzheimer disease: Using bioinformatics, a dual-luciferase reporter assay, gain- and loss-of-function experiments, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot analyses, KLF4 was identified as a mediator of the effect of miR-25802 on microglia-mediated neuroinflammation in AD, both in vitro and in vivo.