This was associated with elevated expression of pro-migratory and pro-inflammatory molecules such as IL-6, cyclooxygenase-2, membrane type 1 metalloprotease, phospholipase A2, and transforming growth factor-β (TGF-β), which likely facilitated the migration of cancer cells, increased circulating tumor cells, and metastasis to the lungs. This evidence concerns the gene MMP14 and cancer.