However, there are limited reports on the regulation of m6A methylation modification on metabolism in gliomas.Ruan C et al’s research highlights the role of METTL3 in promoting aerobic glycolysis in glioma cells through the regulation of the m6A/miR-27b-3p/PDK1 signaling pathway, which is crucial for the tumorigenic metabolism and proliferation of glioma cells (115).Interestingly, a study by Zhang J et al. The gene discussed is PDK1; the disease is central nervous system cancer.