Targeting HPRT may offer a novel therapeutic approach for treating lung cancer (75).It has been highlighted that blocking equilibrative nucleoside transporter 1 with CNX-774 can overcome resistance to dihydroorotate dehydrogenase inhibition, offering a promising approach to treating pancreatic cancer that has become resistant to current therapeutic strategies (76).Nathanson DA et al. Here, HPRT1 is linked to lung carcinoma.