The levels of cytokines, including IL-6, IL-1β, IL-10, IFN-γ, tumor necrosisfactor-α (TNF-α), and colony-stimulating factor (CSF), gradually increase with theseverity of COVID-19 and play a crucial role in the immune response to SARS-CoV-2 infection (10, 32). This evidence concerns the gene TNF and COVID-19.