Moreover, variations in the BDNF gene, responsible for encoding brain-derived neurotrophic factors, have been associated with cognitive deterioration and the effectiveness of treatment in patients with AD (Wright and Van der Flier, 2014; Lim et al., 2014; Jagust et al., 2018; Venegas and Heneka, 2017). Here, BDNF is linked to Alzheimer disease.