In a BLM-induced rat model of pulmonary fibrosis, it was found that BLM disrupts the balance between oxidant/antioxidant defense mechanisms and induces oxidative stress by decreasing the activity of SOD and GPx, which leads to elevated levels of the lipid peroxidation marker MDA, and zingerone treatment reversed these changes. The gene discussed is SOD1; the disease is pulmonary fibrosis.