SOD1 and pulmonary fibrosis: In the experimental models of pulmonary fibrosis induced by BLM (bleomycin), cigarette smoke, and paraquat, it was observed that natural ingredients could reduce lipid peroxidation toxic products (such as MDA, 4-HNE), enhance antioxidant enzyme activities such as SOD, GPx, CAT, regulate the Nrf2 pathway, reduce lipid peroxidation induced lung tissue damage.