MAPT and Alzheimer disease: Immunocytes, particularly microglia and astrocytes, play a pivotal role in the pathogenesis of AD by modulating neuroinflammation (Princiotta Cariddi et al., 2022), Aβ clearance (Ennerfelt et al., 2022; Hur et al., 2020), and tau pathology (Rajesh and Kanneganti, 2022).