Within the central nervous system (CNS), pathogenic proteins associated with AD, such as tau and amyloid-beta (Aβ) oligomers, have been detected in brain-derived EVsand are implicated in AD pathogenesis (DeLeo and Ikezu, 2018; Guo et al., 2016; Dinkins et al., 2014; Bulloj et al., 2010; Yuyama et al., 2012). Here, MAPT is linked to Alzheimer disease.