APP and early-onset autosomal dominant Alzheimer disease: As illustrated in Figure 7C, the top 10 keywords with the highest outbreak intensity include “amyloid precursor protein,” “transgenic mice,” “release,” “synaptic plasticity,” “blood exosome,” “myeloid microvesicles,” “Alzheimer's disease,” “astrocyte-derived exosome,” “model,” and “dysfunction.” The sustained prominence of these keywords through 2021 highlights the continuing emphasis on pivotal research areas concerning EVs in AD.