MAPT and Alzheimer disease: MiRNAs have emerged as crucial regulators of gene expression, particularly in genes implicated in the pathogenesis of AD, including β-site APP-cleaving enzyme 1 (BACE-1), APP, tau, presenilin, and brain-derived neurotrophic factor (Ramakrishna and Muddashetty, 2019; Smith et al., 2015; Banzhaf-Strathmann et al., 2014; Keifer et al., 2015; Li et al., 2016).