CFTR and myocardial infarction: However, when faced with ischemic conditions such as myocardial infarction (MI), characterized by reparative or replacement fibrosis [4] or non-ischemic conditions involving chronic inflammation and edema, which lead to reactive fibrosis [5], the necrosis or apoptosis of cardiomyocytes (CMs) alongside CF activation result in excessive accumulation of ECM [6].