ACE and hydrops fetalis: Clinically, the treatment of HF has commonly involved employing inhibitors of the renin-angiotensin-aldosterone system (RAAS), including angiotensin-converting enzyme inhibitors (Lisinopril, ramipril, enalapril) and angiotensin II receptor antagonists (losartan, candesartan, and valsartan) [[123], [124], [125]].