USP22 and hepatocellular carcinoma: For example, Ubiquitin-specific protease 22 (USP22) is recognized for its critical role in promoting HCC stemness and contributing to multidrug resistance, thus a galactose-decorated lipopolyplex (Gal-SLP) has been designed as a targeted, cascade-responsive nanoplatform for HCC, enabling the co-delivery of sorafenib and USP22 shRNA to achieve synergistic therapeutic effects (38).