These previous studies suggest that MRI-based radiomics features have the potential to predict Ki-67 expression levels in NPC, and our results indicate that the MRI-based radiomics nomogram developed in this study showed good performance in predicting the Ki-67 index in patients with NPC, with an AUC of 0.841 in the test set. Here, MKI67 is linked to nasopharyngeal carcinoma.