Finally, we can conclude that our compound viscosol (5, 7-dihydroxy-3, 6-dimethoxy-2- (4-methoxy-3- (3-methyl but-2-enyl) phenyl) -4H-chrome-4-one) was found to be a negative regulator of PTP1B gene and contribute to the reversal of inflammatory and insulin resistance at the gene level in adipocytes and hepatocytes of the HFD-STZ–induced diabetic mice model. The gene discussed is PTPN1; the disease is Insulin resistance.