TFE3 and early-onset autosomal dominant Alzheimer disease: Recent reports have validated that TFE3 activation enhances autophagy, exerting neuroprotective effects in models of spinal cord injury and Alzheimer's disease.18, 19, 20 Moreover, our recent findings demonstrated that TFE3 activation enhances autophagy, providing protective effects in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced PD model.21