RAG1 and RAG2 mutation or deficiency lead to impaired V(D)J recombination and blocked B cell and T cell differentiation, and are associated with many types of immunodeficiency diseases,113 such as severe combined immunodeficiency (including T and B cell deficiency), Omenn syndrome, leaky severe combined immunodeficiency (production of small amounts of functional T cells, B cells, and immunoglobulins in the body and no clinical features of tumor (osteosarcoma)), and combined immunodeficiency with granuloma or autoimmunity.114. Here, RAG1 is linked to combined immunodeficiency.