The mutation of MRE11 is associated with immune diseases such as ataxia-telangiectasia-like disease and cancers.24, 25, 26 The N-terminus of MRE11 contains a nuclease structural domain essential for HR, and N-terminal mutations lead to structural and functional defects in MRE11 and have effects in the MRE11/NBS1/RAD50 complex. Here, MRE11 is linked to cancer.