Also, reports have proposed that activated CAFs are recovered to normal static fibroblasts by targeting signaling pathway downstream molecules, such as C-X-C motif chemokine ligand 12 (CXCL12), CXCR4, and anti-connective tissue growth factor (CTGF).131, 132, 133 Therefore, these results all implied that targeting CAFs can be a future direction for tumor treatment (Table 3). This evidence concerns the gene CXCL12 and neoplasm.