FBXW2 promotes MMP2, MMP7, and MMP9 expression by forming the β-Trcp/FBXW2/SKP2 axis with other ubiquitin ligases such as β-Trcp and SKP2.145, 146, 147 The latest report proposes that FBXW2 overexpression in breast cancer leads to p65 ubiquitination, eliminating the effect of p65 resistance on paclitaxel use.146. Here, FBXW2 is linked to breast cancer.