BTRC and breast carcinoma: FBXW2 promotes MMP2, MMP7, and MMP9 expression by forming the β-Trcp/FBXW2/SKP2 axis with other ubiquitin ligases such as β-Trcp and SKP2.145, 146, 147 The latest report proposes that FBXW2 overexpression in breast cancer leads to p65 ubiquitination, eliminating the effect of p65 resistance on paclitaxel use.146