In lung adenocarcinoma, under the action of microRNAs secreted by tumor cells, macrophages exhibit inhibition of the ubiquitination and degradation of misshapen-like kinase 1 through a series of pathway reactions (Fig. 4A), which ultimately activates the downstream c-Jun N-terminal kinase signaling pathway and polarizes the macrophages toward M2-like macrophages and thus promotes tumor progression.107. This evidence concerns the gene MINK1 and neoplasm.