Aouichat et al demonstrated melatonin's anti-obesogenic properties and renal protective effects by suppressing ER stress and the IRE1α/JNK (c-Jun N-terminal kinase) apoptotic pathway in Zücker diabetic fatty rats, potentially offering relief from ER stress-related kidney damage in obesity and diabetes.35 This evidence concerns the gene MAPK8 and obesity due to melanocortin 4 receptor deficiency.