Notably, CXCL12 stimulated the AKT/NF-κB pathway, whereas CXCL12 neutralizing attenuated the stimulation (Figure 6B), indicating CXCL12 mediated AKT/NF-κB pathway activation by iCAFs, EMT is a critical step for tumor metastasis. This evidence concerns the gene CXCL12 and neoplasm.