We found the T2 inflammatory cytokine IL-33, total IgE, and GM-CSF, chemokines such as CCL-3 and CCL-4 were significantly higher than in CRSwNP group (P < 0.001, <0.001, <0.001, <0.001, and 0.002, respectively). This evidence concerns the gene IGHE and chronic rhinosinusitis with nasal polyps.