However, the clinical improvement of these biologics for CRSwNP showed heterogeneity in these studies because of the diversity of inflammation within and between the endotypes which could not be reflected by the criteria of type 2 utilized now, which were mainly based on similar biomarkers such as serum IgE level or blood eosinophils combined with clinical disorders. The gene discussed is IGHE; the disease is chronic rhinosinusitis with nasal polyps.