IgG4 reduces the expression of CD206, CD163, and CD14 on the surface of M2 macrophages, increases the production of CCL-1, IL-10, and IL-6, induces the M2b-like macrophage phenotype, which impairs the tumor cell phagocytosis function and the function of anti-cancer effector cells.7 The gene discussed is IL10; the disease is neoplasm.