Previous study has found that IgG4 inhibited IFNγ signaling via FcγRI, and favoring an M2b-like phenotype,72 which plays a role in the formation of CTCL by secreting various chemokines,52 such as CCL-1, IL-10, and IL-6.68 This evidence concerns the gene IL6 and primary cutaneous T-cell non-Hodgkin lymphoma.