TREM2 and ischemic stroke: The results of the western blot showed that ischemic stroke downregulated the expression of TREM2 at the protein level in the hippocampus while EE reversed its effect (p < 0.05 for Sham+SE vs. PT + SE; p < 0.05 for Sham+SE vs. Sham+EE; p < 0.01 for PT + SE vs. PT + EE; Figures 5A,B).