TREM2 is pivotal in modulating immune responses, inflammation, and neuroprotection, positioning it as a promising therapeutic target for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis (Cignarella et al., 2020; Zhang et al., 2023; Huang et al., 2024). This evidence concerns the gene TREM2 and neurodegenerative disease.