GTF2E1 and trichothiodystrophy: Mo and Chae (2021) showed that GTF2E1 protein expression decreased in colorectal cancer tissues compared to adjacent nontumor tissues. Phan et al. (2021) showed that mutations in TFIIE due to disrupted ribosomal biogenesis and translational accuracy cause a loss of protein homeostasis (proteostasis), which can moderately explain the clinical phenotype in trichothiodystrophy. Moreover, Kuschal et al. (2016) showed that individuals with trichothiodystrophy have mutations in the basal transcription factor GTF2E2 with normal DNA repair.