The modulation of numerous signaling pathways involved in melanoma progression, such as the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B (AKT) pathways, has been engaged in the regulation of cell proliferation, differentiation, and apoptotic cell death in melanoma cells (Sattar et al., 2021; Lee et al., 2023). Here, WNK2 is linked to melanoma.