CDKN2A and melanoma: Likewise, the CDKN2A gene was upregulated in the B16F10 melanoma cells when treated with 123 μM of ATRA, 136 μM of SM, and the 123 μM ATRA+136 μM SM combination, indicating consistency with the literature, in which germ-line mutations in the CDKN2A tumor-suppressor gene were related to the pathogenesis of hereditary melanoma, specifically concerning the development of melanoma.