A study explored the association between the GST genetic polymorphisms and methamphetamine abusers in the Japanese population and found that individuals with the GSTP1 Ile105Val variant had a significantly higher risk of methamphetamine abuse compared to individuals with the wild-type genotype (10), which is consistent with the broader literature on genetic risk factors for substance abuse, implying that genetic variation may influence susceptibility to addiction (25). This evidence concerns the gene GSTP1 and substance abuse.