Additionally, HuMSC-Exo has been found to reduce joint swelling and synovial hyperplasia in RA mice, decrease proinflammatory cytokines and IgG in serum, and restore the balance between Th17 and Treg cells by down-regulating IL-17 in serum and promoting TGF-β and IL-10 (Fu et al. 2022). This evidence concerns the gene IL17A and rheumatoid arthritis.