Relative to the control group, the TGR5 protein content in the small intestine of rats in the model group was notably reduced (P < 0.01), suggesting that SZ-A can notably suppress the activation of TGR5 in the rat small intestine caused by obesity and inhibit the expression of TGR5 (Figures 7A–F). The gene discussed is GPBAR1; the disease is obesity due to melanocortin 4 receptor deficiency.