Karlsen et al40 in a short-term, 4-week trial in subjects at increased risk of CVD, showed that bilberry juice supplementation decreased plasma CRP and IL-6, while green tea supplementation for 8 weeks showed no effects on these inflammatory parameters in subjects with metabolic syndrome.41 Our finding was also in contrast with the results of an 8-week interventional study by Basu et al26 that showed no significant effects of cranberry juice intervention on interleukin-6 (IL-6) and C-reactive protein (CRP) in subjects with metabolic syndrome. The gene discussed is CRP; the disease is metabolic syndrome.