IL1B and periodontal disorder: In both periodontal diseases and DM, the major inflammatory markers with both local (periodontal destruction) and systemic (impaired glycemic control) effects are involved.2,3 It is indicated that in type 2 diabetic patients with periodontal disease, the levels of inflammatory markers such as C-reactive protein, IL-1β, TNF-α, and IL-6 are high, which may adversely affect blood glucose and lipid metabolism.4 The imbalance between reactive oxygen species (ROS) production and antioxidant defenses leads to oxidative stress.