In both periodontal diseases and DM, the major inflammatory markers with both local (periodontal destruction) and systemic (impaired glycemic control) effects are involved.2,3 It is indicated that in type 2 diabetic patients with periodontal disease, the levels of inflammatory markers such as C-reactive protein, IL-1β, TNF-α, and IL-6 are high, which may adversely affect blood glucose and lipid metabolism.4 The imbalance between reactive oxygen species (ROS) production and antioxidant defenses leads to oxidative stress. The gene discussed is TNF; the disease is diabetes mellitus.