Notably, by activating the kinin BK2 receptor signaling in the ischemic brain vasculature, KLK1 stimulates 3 different vasoactive pathways at once: NO, prostacyclin, and endothelium-derived hyperpolarizing factor, thereby ensuring a maximal and coordinated response even in conditions of endothelial dysfunction.40 In addition, activation of the BK2 receptor has been shown in animal models to transactivate the VEGF receptor, which stimulates angiogenesis and cellular repair mechanisms.41 An extended course of therapy for weeks after the AIS is expected to support and sustain these effects. The gene discussed is KLK1; the disease is androgen insensitivity syndrome.