On the other hand, cisplatin-resistant tumor cells induce apoptosis of CTLs by secreting plasma gelsolin (pGSN) and exosome-a type of small extracellular vesicle (sEV), which leads to a decrease in IFN-γ secretion and renders the tumor cells resistant to cisplatin-induced apoptosis [114]. This evidence concerns the gene IFNG and neoplasm.