Increased p16 expression is detected in neurons around amyloid beta (Aβ) plaques or tau tangle‐bearing neurons in the brains of human AD patients and AD mouse models (Arendt et al. 1996; Herdy et al. 2022; McShea et al. 1997; Musi et al. 2018; Wei et al. 2016). This evidence concerns the gene MAPT and Alzheimer disease.