APOE and dementia: One of the three iPSC lines (fAD with PSEN1 mutation) had a normal karyotype in 20 of 20 cells examined, while the other two lines (sAD with APOE4/E4 and Ctrl with no dementia) had abnormal karyotypes with an interstitial duplication in chromosome 20q in 6 and 9 of 20 cells examined, respectively (Figure S1B).