CDKN2A and Alzheimer disease: As p16 expression is elevated during aging in many types of tissues and cells including brain and neurons (Herdy et al. 2022; Krishnamurthy et al. 2004), our study suggests that age‐associated up‐regulation of p16 could play an important role in AD by enhancing tau phosphorylation, thus providing a potential mechanism of aging contributing to AD pathology.