In addition to neurons, the expression of p16 has been found to increase in astrocytes, microglia, and oligodendrocyte precursor cells in the brain tissues of human AD patients and mouse AD models (Arendt et al. 1996; Bhat et al. 2012; Bussian et al. 2018; Herdy et al. 2022; Musi et al. 2018; Wei et al. 2016; Zhang et al. 2019). The gene discussed is CDKN2A; the disease is Alzheimer disease.