In the brains of human AD patients and AD mouse models, p16 is often detected in neurons around amyloid plaques or in tau tangle‐bearing neurons (Arendt et al. 1996; Herdy et al. 2022; McShea et al. 1997; Musi et al. 2018; Wei et al. 2016). Here, CDKN2A is linked to Alzheimer disease.