Further, increased p16 expression is reported in various types of cells (astrocytes, microglia, oligodendrocyte precursor cells, and neurons) in AD mouse models and human post‐mortem AD brains (Arendt et al. 1996; Bhat et al. 2012; Bussian et al. 2018; Dehkordi et al. 2021; Gaikwad et al. 2021; Herdy et al. 2022; McShea et al. 1997; Musi et al. 2018; Wei et al. 2016; Zhang et al. 2019). Here, CDKN2A is linked to Alzheimer disease.