SLC1A5, SLC3A2, and SLC7A5 are well‐documented amino acid transporters that mediate the cross‐membrane flux of large neutral amino acids which are reported to be upregulated and act as contributors in different types of cancer.[38, 52, 53, 54] To date, ≈60 members of the solute carrier family have been reported to be involved in cross‐membrane amino acid transport in mammalian cells.[55] Interestingly, nearly half of the known amino acid transporters positively correlated with RTN4IP1 in ESCA, of which 14 were downregulated upon RTN4IP1 deficiency. The gene discussed is SLC1A5; the disease is cancer.