RTN4IP1 knockdown promotes cell proliferation, invasion and migration, as well as colony and sphere formation in vitro.[15] Van de Vijver and colleagues reported a 14‐gene expression signature specific to visceral metastasis in breast cancer, implying the involvement of RTN4IP1 in metastasis.[16] Another study on germinal center B‐cell type diffuse large B‐cell lymphoma identified RTN4IP1 as a super‐enhancer‐related and survival‐associated gene.[17] However, the role of RTN4IP1 in cancer and the underlying regulatory mechanism governing its expression remain unclear. This evidence concerns the gene RTN4IP1 and breast cancer.