We further demonstrate that c‐Myc–IRP2–IRE axis is responsible for the upregulation of RTN4IP1, and identify SLC1A5, SLC3A2, and SLC7A5, three amino acid transporters implicated in cancer, as essential downstream effectors of RTN4IP1 in ESCC. Here, SLC1A5 is linked to esophageal squamous cell carcinoma.