114). By producing IL-10, B cells block the immune response of Th1 and Th-17 cells, reducing their proinflammatory activity (Ref. 115). IL-35 is a recently discovered anti-inflammatory cytokine from the IL-12 family produced by a wide range of regulatory lymphocytes. It has an important role in blocking the development of Th1 and Th17 cells (Ref. 116). In a study conducted by Aksoy et al. (Ref. 117), the level of IL-35 was significantly lower in people with AP compared with healthy people, this marker being considered in the diagnosis and follow-up of patients with AP. The gene discussed is IL10; the disease is alkaline phosphatase measurement.