Many cytosolic and nuclear lysine modifications have been identified, including ubiquitination, acetylation, methylation, and succinylation.47,48l-lactylation of lysine residues is initially detected on histones in the nucleus of macrophages,16 then on MRE11 and p53 in cancer cells,18,19 mitochondrial enzymes in myoblast cells, and α-myosin in myocardial cells.21 However, SLG-induced lactylation provides another type of lysine modification, d-lactylation, a stereoisomer of l-lactylation. This evidence concerns the gene MRE11 and cancer.