In addition, using SKM-1 cells (acute myeloid leukaemia [AML] cell line harbouring a TET2 mutation), the authors could also demonstrate that a MBD6 knock-down resulted in a complete growth inhibition of these AML cells with comparable results seen for NSUN knock-out cells, and similar findings have been found for human hematopoietic stem and progenitor cells. Here, MBD6 is linked to acute myeloid leukemia.