FUS and amyotrophic lateral sclerosis: FUS is an RNA-binding protein that plays a critical role in gene transcription and RNA processing, forming condensates essential for cellular stress responses and organizational functions.618 However, under pathological conditions, these condensates can transition into solid aggregates, which are implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).619,620