The Non-POU domain-containing octamer-binding protein (NONO) is frequently upregulated in various human cancers, particularly glioblastoma (GBM), where its expression correlates strongly with disease development, aggressiveness, and patient survival.187,188 Wei et al. identified NONO as a critical TAZ-interacting protein in the nucleus, essential for TAZ activation by enhancing accessibility to transcriptional enhancers. The gene discussed is NONO; the disease is cancer.