Mutations in the NF2 gene, whether germline or somatic, are the primary etiological factors for type 2 neurofibromatosis, a condition associated with a predisposition to various malignancies.207–210 In a recent study, Meng et al. proposed a novel pathogenic mechanism by which NF2 mitigates the inhibition of TANK-binding kinase 1 (TBK1) by reducing the function of YAP/TAZ and thereby facilitating the innate sensing of nucleic acids. Here, NF2 is linked to neurofibromatosis.