SFPQ, an RNA-binding protein ubiquitously expressed in cells, is involved in alternative splicing, transcriptional regulation, and the formation of paraspeckles in association with ALS-associated RBPs TDP-43 (TAR DNA-binding protein 43) and FUS.278 Notably, SFPQ is frequently upregulated in various human cancers and has been suggested as a potent suppressor of TGF-β signaling pathways. Here, TARDBP is linked to amyotrophic lateral sclerosis.