CXCL8 and neoplasm: This approach highlighted several putative iCAF-enriched populations from both normal and tumour samples; in normal tissues these included Stress-response Fib, CXCL8 + Breast Fib and universal (PI16+) fibroblasts; in tumours, IL11 + CAF, IGF1 + CAF and proto-CAF (Fig. 6A).