IL11 and colorectal carcinoma: The HNSCC iCAF resided in the IL11 + CAF cluster (Supplementary Fig. 9B); this semi-conserved phenotype was one of the most abundant fibroblast subpopulations in HNSCC, colorectal carcinoma (CRC) and oesophageal squamous cell carcinoma (ESCC) (Supplementary Fig. 9A) but was not present in lung or breast cancers.