Tissue-specific subsets included CXCL8 + breast fibroblasts [most abundant subset (>85%) in normal breast tissue], NPNT+ (alveolar) lung fibroblasts and F3+/ADAMDEC1 + colonic/gastric fibroblasts (all found in normal and tumour samples; Fig. 5D, E). Here, CXCL8 is linked to neoplasm.