Using a frequently used iCAF gene signature [5], we identified several fibroblast clusters enriched in the pan-cancer analysis that shared expression of genes such as CXCL8, CXCL1, CXCL2, IL6, with some phenotypes present in normal tissue (e.g., CXCL8 + breast fibroblasts; a similar fibroblast population has been described previously in breast tissue as ‘Fibro-major’ [46]). Here, CXCL2 is linked to cancer.