PX‐478, a hypoxia‐inducible factor‐1α (HIF‐1α) inhibitor, and BPR0C261, a microtubule‐disrupting agent, were administrated into tumour‐bearing mice established using murine MTCQ1 tongue cancer cells through intraperitoneal injection and oral gavage, respectively. The gene discussed is HIF1A; the disease is neoplasm.