Using intestinal samples and peripheral blood mononuclear cells (PBMCs) from patients with IBD harboring the autoimmune PTPN2 risk allele in SNP rs1893217, IEC lines modified by CRISPR-Cas9 to express the PTPN2 rs1893217 variant, PTPN2-knockdown (KD) human intestinal and lung epithelial cell lines as well as Ptpn2-deficient mouse models, we determined that loss of PTPN2 activity promotes ACE2 expression and increased entry of viral particles expressing SARS-CoV-2 spikes. The gene discussed is ACE2; the disease is inflammatory bowel disease.