For example, YTHDC1 has been reported to mitigate cellular senescence-induced pulmonary fibrosis by facilitating the interaction between DNA topoisomerase 2-binding protein 1 (TopBP1) and Meiotic Recombination 11 (MRE11), thereby enhancing DNA damage repair [33]. The gene discussed is TOPBP1; the disease is pulmonary fibrosis.