Many of the genetic variants linked to schizophrenia risk implicate NMDARs and other glutamate signaling proteins, and recent efforts have attempted to link these genetic variants to functional measures of the glutamate system in humans.100 Collectively, these data suggest that DAAO inhibitors, and other NMDAR modulators, could impact neuronal function differentially in patients with different genetic backgrounds. This evidence concerns the gene DAO and schizophrenia.